SCHEMBL19982612

SCHEMBL19982612

CCOP(Cc1ccc(COc2ccccc2CN2CCN(Cc3ccc4nc(-c5cccc(C(F)(F)F)c5)[nH]c4c3)CC2)cc1)OCC

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
SLC2A1 P11166 2/20 0.41
HTR2A P28223 1/20 0.40
HTR2C P28335 1/20 0.40
CNR2 P34972 7/20 0.39
NPSR1 Q6W5P4 2/20 0.39
KDM4E B2RXH2 1/20 0.39
ALDH1A1 P00352 1/20 0.39
PTGDR2 Q9Y5Y4 1/20 0.39
DRD4 P21917 1/20 0.39
DRD3 P35462 1/20 0.39
TMEM97 Q5BJF2 1/20 0.39
SIGMAR1 Q99720 1/20 0.39
CNR1 P21554 3/20 0.38
KCNH2 Q12809 2/20 0.38
NPBWR1 P48145 1/20 0.38
LMNA P02545 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19982579 0.93 SLC2A1 (0.44) SLC2A1PTGDR2KCNH2NPBWR1FGFR1
SCHEMBL19982610 0.86 SLC2A1 (0.42) CYP1A2CYP3A4CYP2C9CYP2C19SLC2A1
SCHEMBL19982585 0.84 DRD4 (0.42) CYP1A2CYP3A4CYP2C9CYP2C19SLC2A1
SCHEMBL19970766 0.84 SLC2A1 (0.46) CYP1A2CYP3A4CYP2C9CYP2C19SLC2A1
SCHEMBL19982583 0.83 SLC2A1 (0.42) CYP1A2CYP3A4CYP2C9CYP2C19SLC2A1
SCHEMBL19982654 0.79 DRD4 (0.43) SLC2A1DRD4DRD3TMEM97SIGMAR1
SCHEMBL19970765 0.79 SLC2A1 (0.41) SLC2A1CNR2KDM4EALDH1A1CNR1
SCHEMBL19982578 0.79 SLC2A1 (0.45) SLC2A1PTGDR2KCNH2NPBWR1FGFR1
SCHEMBL19970804 0.79 CNR2 (0.40) CYP1A2CYP3A4CYP2C9CYP2C19SLC2A1
SCHEMBL19982561 0.77 SLC2A1 (0.46) SLC2A1HTR2AHTR2CDRD4DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018050771-A1 BENZIMIDAZOL DERIVATIVES FOR TREATING FILOVIRUS INFECTION CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2018-03-22 WO disclosed
EP-3296297-A1 BENZIMIDAZOL DERIVATIVES FOR TREATING FILOVIRUS INFECTION CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2018-03-21 EP disclosed