SCHEMBL19982667

SCHEMBL19982667

Bc1cc(NCP(=O)(O)O)cc(C(F)(F)F)c1Oc1ccc(O)c(C(C)C)c1

nearest known ligand 0.67

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
THRA P10827 14/20 0.67
THRB P10828 14/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21291336 0.90 THRA (0.67) THRATHRB
SCHEMBL282524 0.89 THRA (0.81) THRATHRB
SCHEMBL13381729 0.83 THRA (0.70) THRATHRB
SCHEMBL13382063 0.80 THRA (1.00) THRATHRB
SCHEMBL282338 0.80 THRA (1.00) THRATHRB
SCHEMBL3162118 0.78 THRB (0.63) THRATHRB
SCHEMBL13382126 0.74 THRA (0.66) THRATHRB
SCHEMBL4210679 0.74 THRA (0.67) THRATHRB
SCHEMBL13381630 0.73 THRA (0.85) THRATHRB
SCHEMBL3157141 0.73 THRA (0.85) THRATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018053036-A1 METHOD OF REDUCING THYROID-ASSOCIATED SIDE EFFECTS VIKING THERAPEUTICS, INC. (US) 2018-03-22 WO disclosed