Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 8/20 | 0.35 |
| ▸ | JAK2 | O60674 | 7/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19983166 | 0.79 | SYK (0.40) | SYKEIF2AK4JAK1JAK2 | |
| SCHEMBL19982840 | 0.79 | SYK (0.40) | SYKEIF2AK4JAK1JAK2 | |
| SCHEMBL19983154 | 0.78 | SYK (0.42) | SYKEIF2AK4JAK1JAK2 | |
| SCHEMBL19982833 | 0.77 | SYK (0.42) | SYKEIF2AK4JAK1JAK2 | |
| SCHEMBL15210838 | 0.76 | SYK (0.45) | SYKEIF2AK4ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL19982766 | 0.76 | SYK (0.37) | SYKEIF2AK4JAK1JAK2 | |
| SCHEMBL15212878 | 0.75 | SYK (0.47) | SYKEIF2AK4JAK1JAK2 | |
| SCHEMBL19982813 | 0.75 | SYK (0.43) | SYKEIF2AK4JAK1JAK2 | |
| SCHEMBL15221165 | 0.75 | SYK (0.46) | SYKEIF2AK4JAK1JAK2 | |
| SCHEMBL15210618 | 0.74 | SYK (0.46) | SYKEIF2AK4JAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2817310-B1 | 8-SUBSTITUTED 2-AMINO-[1,2,4]TRIAZOLO[1,5-A]PYRAZINES AS SYK TRYROSINE KINASE INHIBITORS AND GCN2 SERIN KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2018-03-21 | — | — | EP | disclosed |