SCHEMBL19982838

SCHEMBL19982838

Nc1ncnc2c1c(C#CCNC(=O)CCCCCNC(=O)CCCC[C@@H]1SC[C@@H]3NC(=O)N[C@@H]31)cn2[C@H]1C[C@H](O)[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O1

nearest known ligand 0.49

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
HLCS P50747 3/20 0.49
PLCD1 P51178 1/20 0.47
F2 P00734 1/20 0.42
HINT1 P49773 1/20 0.42
FGF1 P05230 1/20 0.41
FGF2 P09038 1/20 0.41
VEGFA P15692 1/20 0.41
HPSE Q9Y251 1/20 0.41
DTYMK P23919 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22897369 0.92 HLCS (0.47) HLCSPLCD1F2HINT1FGF1
SCHEMBL29592014 0.91 PLCD1 (0.44) HLCSPLCD1F2HINT1
SCHEMBL20129500 0.91 F2 (0.47) HLCSPLCD1F2FGF1FGF2
SCHEMBL22192980 0.91 HLCS (0.46) HLCSPLCD1F2HINT1FGF1
SCHEMBL20126980 0.91 F2 (0.47) HLCSPLCD1F2FGF1FGF2
SCHEMBL20130787 0.90 PLCD1 (0.48) HLCSPLCD1F2FGF1FGF2
SCHEMBL20417307 0.86 POLB (0.42) DTYMK
SCHEMBL20417316 0.86 POLB (0.42) DTYMK
SCHEMBL22623187 0.86 HLCS (0.41) HLCSF2HINT1
SCHEMBL20234146 0.85 PLCD1 (0.46) HLCSPLCD1F2HINT1FGF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11795492-B2 Methods of nucleic acid sample preparation ArcherDX, LLC. (US) 2023-10-24 US disclosed
US-11795492-B2 Methods of nucleic acid sample preparation ArcherDX, LLC. (US) 2023-10-24 US disclosed
EP-4198140-A1 METHODS OF NUCLEIC ACID SAMPLE PREPARATION FOR IMMUNE REPERTOIRE SEQUENCING ArcherDX, LLC (US) 2023-06-21 EP disclosed
US-20210180118-A1 METHODS OF NUCLEIC ACID SAMPLE PREPARATION FOR IMMUNE REPERTOIRE SEQUENCING ARCHERDX, LLC (US) 2021-06-17 US disclosed
US-20210054435-A1 METHODS OF NUCLEIC ACID SAMPLE PREPARATION ArcherDX, Inc. (US) 2021-02-25 US disclosed
US-10704082-B2 Methods of nucleic acid sample preparation ArcherDX, Inc. (US) 2020-07-07 US disclosed
US-10683531-B2 Methods of nucleic acid sample preparation for analysis of cell-free DNA ArcherDX, Inc. (US) 2020-06-16 US disclosed
US-20180127807-A1 METHODS OF NUCLEIC ACID SAMPLE PREPARATION FOR ANALYSIS OF CELL-FREE DNA ArcherDX, Inc. (US) 2018-05-10 US disclosed
US-20180127806-A1 METHODS OF NUCLEIC ACID SAMPLE PREPARATION ArcherDX, Inc. (US) 2018-05-10 US disclosed
WO-2018053362-A1 METHODS OF NUCLEIC ACID SAMPLE PREPARATION ArcherDX, Inc. (US) 2018-03-22 WO disclosed
WO-2018053365-A1 METHODS OF NUCLEIC ACID SAMPLE PREPARATION FOR ANALYSIS OF CELL-FREE DNA ArcherDX, Inc. (US) 2018-03-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210180118-A1 METHODS OF NUCLEIC ACID SAMPLE PREPARATION FOR IMMUNE REPERTOIRE SEQUENCING TLR9, HAVCR2, IGSF11 HLCS 1870/4885PLCD1 2982/4885F2 3361/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.