SCHEMBL19982883

SCHEMBL19982883

CO/C(=C\C(C)=N)NC(C)=O

nearest known ligand 0.33

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
TAS2R38 P59533 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14546722 0.73
SCHEMBL5440136 0.67
SCHEMBL12859161 0.65 ALDH1A1 (0.35) ALDH1A1
SCHEMBL23960743 0.64 ALDH1A1 (0.37) ALDH1A1
SCHEMBL13780097 0.64 ALDH1A1 (0.37) ALDH1A1
SCHEMBL26073498 0.64 CRBN (0.38) CRBNTAS2R38
SCHEMBL1070826 0.63 CRBN (0.47) CRBNALDH1A1TAS2R38
SCHEMBL3082306 0.63
SCHEMBL2326348 0.62 SMN1; SMN2 (0.50) CRBNALDH1A1TAS2R38
SCHEMBL2326353 0.62 SMN1; SMN2 (0.50) CRBNALDH1A1TAS2R38

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2881394-B1 CONDENSED RING HETEROCYCLIC COMPOUND KYOWA HAKKO KIRIN CO LTD (JP) 2018-03-21 EP disclosed