Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | APLNR | P35414 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19983031 | 0.76 | SCN9A (0.40) | KMT2ASCN9ACTSSCTSKRAB9A | |
| SCHEMBL14988879 | 0.76 | KMT2A (0.48) | LMNAKMT2AALDH1A1MAPTKDM4E | |
| SCHEMBL19982963 | 0.75 | CYP3A4 (0.49) | KDM4ESCN9A | |
| SCHEMBL19983074 | 0.74 | KMT2A (0.40) | LMNAKMT2AHTTSCN9ACTSS | |
| SCHEMBL10020389 | 0.72 | CTSK (0.42) | CTSSCTSK | |
| SCHEMBL10052107 | 0.72 | CTSK (0.42) | CTSSCTSK | |
| SCHEMBL4832334 | 0.72 | SMN1; SMN2 (0.43) | LMNATSHRKMT2AALDH1A1MAPT | |
| SCHEMBL23796281 | 0.71 | SCN9A (0.43) | KDM4ESCN9ACTSSCTSK | |
| SCHEMBL19983110 | 0.71 | KMT2A (0.40) | KMT2ACTSKRAB9A | |
| SCHEMBL22307832 | 0.71 | HPGD (0.37) | LMNAKMT2ACTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018053353-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2018-03-22 | — | — | WO | disclosed |