Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29340379 | 0.85 | TBXAS1 (0.50) | SMN1; SMN2HTTKMT2APOLBALDH1A1 | |
| SCHEMBL28897181 | 0.80 | CYP1A2 (0.59) | SMN1; SMN2POLBALDH1A1NPC1RAB9A | |
| SCHEMBL9398031 | 0.77 | SMN1; SMN2 (0.42) | SMN1; SMN2HTTKMT2APOLBPKM | |
| SCHEMBL24883553 | 0.76 | ATM (0.45) | KMT2APOLBALDH1A1LMNAHPGD | |
| SCHEMBL21646286 | 0.75 | ALDH1A1 (0.46) | SMN1; SMN2HTTKMT2APOLBPKM | |
| SCHEMBL24883481 | 0.75 | PTGS1 (0.38) | HTTKMT2APOLBALDH1A1LMNA | |
| SCHEMBL31425815 | 0.75 | ALDH1A1 (0.46) | SMN1; SMN2HTTKMT2APOLBPKM | |
| SCHEMBL19983131 | 0.74 | CYP3A4 (0.52) | SMN1; SMN2HTTKMT2AALDH1A1LMNA | |
| SCHEMBL2775739 | 0.74 | ALDH1A1 (0.47) | HTTKMT2APOLBALDH1A1NPC1 | |
| SCHEMBL25224056 | 0.74 | MAPK1 (0.50) | KMT2APOLBALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018053353-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2018-03-22 | — | — | WO | disclosed |