Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSH | P09668 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19983008 | 0.89 | CTSH (0.41) | CTSHCTSKTDP1PAX8ATM | |
| SCHEMBL19983057 | 0.89 | CTSH (0.41) | CTSHCTSKTDP1PAX8ATM | |
| SCHEMBL19983290 | 0.89 | CTSH (0.41) | CTSHCTSKTDP1PAX8ATM | |
| SCHEMBL19983025 | 0.88 | CTSH (0.46) | CTSHCTSKTDP1PAX8ATM | |
| SCHEMBL21152692 | 0.85 | CTSK (0.47) | CTSHCTSKTDP1PAX8ATM | |
| SCHEMBL19983311 | 0.85 | CA1 (0.51) | CTSHCTSKTDP1PAX8KDM4E | |
| SCHEMBL19983289 | 0.84 | FOLH1 (0.47) | CTSHCTSKTDP1PAX8ATM | |
| SCHEMBL19982961 | 0.84 | CTSK (0.44) | CTSHCTSKTDP1PAX8 | |
| SCHEMBL19983003 | 0.84 | CTSK (0.44) | CTSHCTSKTDP1PAX8 | |
| SCHEMBL19665687 | 0.83 | CTSK (0.40) | CTSHCTSKTDP1ATMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018053353-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2018-03-22 | — | — | WO | disclosed |