Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10498542 | 0.87 | LMNA (0.70) | LMNAMAPTKDM4EALDH1A1GAA | |
| SCHEMBL6663539 | 0.87 | — | — | |
| SCHEMBL3339822 | 0.77 | KDM4E (0.60) | LMNAMAPTKDM4EALDH1A1GAA | |
| SCHEMBL18228600 | 0.77 | KDM4E (0.60) | LMNAMAPTKDM4EALDH1A1GAA | |
| SCHEMBL2168776 | 0.77 | KDM4E (0.60) | LMNAMAPTKDM4EALDH1A1GAA | |
| SCHEMBL15887432 | 0.76 | LMNA (0.57) | LMNAMAPTKDM4EALDH1A1GAA | |
| SCHEMBL13116773 | 0.76 | LMNA (0.57) | LMNAMAPTKDM4EALDH1A1GAA | |
| SCHEMBL18123286 | 0.76 | LMNA (0.57) | LMNAMAPTKDM4EALDH1A1GAA | |
| SCHEMBL255331 | 0.76 | MAPT (0.57) | LMNAMAPTKDM4EALDH1A1GAA | |
| SCHEMBL12990524 | 0.76 | LMNA (0.57) | LMNAMAPTKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021032933-A1 | ENZYME INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-25 | — | — | WO | disclosed |
| WO-2018053126-A1 | INHIBITION OF BMP SIGNALING, COMPOUNDS, COMPOSITIONS AND USES THEREOF | VANDERBILT UNIVERSITY (US) | 2018-03-22 | — | — | WO | disclosed |