Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL28082091 | 0.97 | KDM4E (0.58) | KDM4EALDH1A1USP2POLBLMNA | |
| Ammonia Solution, Strong SCHEMBL28080150 | 0.97 | KDM4E (0.58) | KDM4EALDH1A1USP2POLBLMNA | |
| Fluoride SCHEMBL28112400 | 0.95 | KDM4E (0.56) | KDM4EALDH1A1USP2POLBLMNA | |
| SCHEMBL18228600 | 0.94 | KDM4E (0.60) | KDM4EALDH1A1USP2POLBLMNA | |
| SCHEMBL3339822 | 0.94 | KDM4E (0.60) | KDM4EALDH1A1USP2POLBLMNA | |
| SCHEMBL28112869 | 0.93 | KDM4E (0.55) | KDM4EALDH1A1USP2POLBLMNA | |
| SCHEMBL2951425 | 0.92 | KDM4E (0.58) | KDM4EALDH1A1USP2POLBLMNA | |
| SCHEMBL1928132 | 0.92 | KDM4E (0.58) | KDM4EALDH1A1USP2POLBLMNA | |
| SCHEMBL139049 | 0.92 | KDM4E (0.58) | KDM4EALDH1A1USP2POLBLMNA | |
| Fluoride SCHEMBL28073285 | 0.90 | KDM4E (0.56) | KDM4EALDH1A1USP2POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2628727-A2 | Biaryl PDE4 inhibitors for treating pulmonary and cardiovascular disorders | Decode Genetics EHF (IS) | 2013-08-21 | — | — | EP | claimed |
| US-20120213758-A1 | BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS | DeCODE Genetics enf (IS) | 2012-08-23 | — | — | US | claimed |
| EP-2222639-A1 | BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS | Decode Genetics EHF (IS) | 2010-09-01 | — | — | EP | claimed |
| US-20090136473-A1 | BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | US | claimed |
| WO-2009067621-A1 | BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | claimed |
| EP-4695239-A1 | DISUBSTITUTED PYRIMIDINE COMPOUNDS FOR KETOHEXOKINASE INHIBITION | Centennial Therapeutics, LLC (US) | 2026-02-18 | — | — | EP | disclosed |
| EP-4547660-A1 | AZETIDINYL PYRIMIDINES AND USES THEREOF AS JAK INHIBITORS | Alcon Inc. (CH) | 2025-05-07 | — | — | EP | disclosed |
| US-20240425496-A1 | AZETIDINYL PYRIMIDINES AND USES THEREOF | ALCON INC. (CH) | 2024-12-26 | — | — | US | disclosed |
| WO-2024216034-A1 | DISUBSTITUTED PYRIMIDINE COMPOUNDS FOR KETOHEXOKINASE INHIBITION | CENTENNIAL THERAPEUTICS, LLC (US) | 2024-10-17 | — | — | WO | disclosed |
| EP-4363058-A1 | AZETIDINYL PYRIMIDINES AND USES THEREOF | Aerie Pharmaceuticals, Inc. (US) | 2024-05-08 | — | — | EP | disclosed |
| EP-4363058-A1 | AZETIDINYL PYRIMIDINES AND USES THEREOF | Aerie Pharmaceuticals, Inc. (US) | 2024-05-08 | — | — | EP | disclosed |
| WO-2023279105-A1 | AZETIDINYL PYRIMIDINES AND USES THEREOF | AERIE PHARMACEUTICALS, INC. (US) | 2023-01-05 | — | — | WO | disclosed |
| CN-105814043-A | Triazolopyridine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| EP-2628727-A2 | Biaryl PDE4 inhibitors for treating pulmonary and cardiovascular disorders | Decode Genetics EHF (IS) | 2013-08-21 | — | — | EP | disclosed |
| EP-2350054-A1 | AZETIDINE DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE | Merck Canada Inc. (CA) | 2011-08-03 | — | — | EP | disclosed |
| US-20110183958-A1 | AZETIDINE DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE | MERCK FROSST CANADA LTD. | 2011-07-28 | — | — | US | disclosed |
| WO-2010043052-A1 | AZETIDINE DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE | MERCK FROSST CANADA LTD. (CA) | 2010-04-22 | — | — | WO | disclosed |
| EP-1056771-B1 | STREPTOGRAMIN DERIVATIVES, PREPARATION METHOD AND COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2005-11-30 | — | — | EP | disclosed |
| EP-1056771-A1 | STREPTOGRAMIN DERIVATIVES, PREPARATION METHOD AND COMPOSITIONS CONTAINING SAME | Aventis Pharma S.A. (FR) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999043699-A1 | STREPTOGRAMIN DERIVATIVES, PREPARATION METHOD AND COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA S.A. (FR) | 1999-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090136473-A1 | BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS | PDE4A, PDE4B, PDE3B | KDM4E 548/4885ALDH1A1 149/4885USP2 2233/4885 |
| US-20110183958-A1 | AZETIDINE DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE | SCD, SCD5, FADS2 | KDM4E 1086/4885ALDH1A1 394/4885USP2 3949/4885 |
| US-20120213758-A1 | BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS | PDE4A, PDE4B, PDE3B | KDM4E 548/4885ALDH1A1 149/4885USP2 2233/4885 |
| US-20240425496-A1 | AZETIDINYL PYRIMIDINES AND USES THEREOF | NME2, UACA, UCK2 | KDM4E 1786/4885ALDH1A1 1657/4885USP2 1708/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.