Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | GLA | P06280 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 2/20 | 0.40 |
| ▸ | CASP7 | P55210 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | ALPG | P10696 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TNFSF11 | O14788 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2048079 | 0.80 | MAPT (0.49) | POLBACHEHTTKDM4EGAA | |
| SCHEMBL31229876 | 0.80 | MAPT (0.49) | POLBACHEHTTKDM4EGAA | |
| SCHEMBL31335867 | 0.78 | KDM4E (0.51) | POLBACHEHTTKDM4EGAA | |
| SCHEMBL12299731 | 0.78 | KDM4E (0.49) | POLBACHEHTTKDM4EGAA | |
| SCHEMBL6220822 | 0.77 | ACHE (0.46) | POLBACHEHTTKDM4EGAA | |
| SCHEMBL29329332 | 0.76 | KDM4E (0.58) | POLBACHEHTTKDM4EGAA | |
| SCHEMBL14585774 | 0.73 | CA1 (0.43) | POLBACHEHTTKDM4EGAA | |
| SCHEMBL16016937 | 0.73 | CYP3A4 (0.38) | POLBACHEKDM4EGAAALDH1A1 | |
| SCHEMBL13021618 | 0.73 | ELANE (0.50) | POLBACHEHTTKDM4EGAA | |
| SCHEMBL2910532 | 0.72 | POLB (0.62) | POLBACHEHTTKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018053313-A1 | ADENOSINE ANALOGS AS METHYLTRANSFERASE INHIBITORS FOR TREATING CANCER | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2018-03-22 | — | — | WO | disclosed |