Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27396276 | 0.90 | SIGMAR1 (0.45) | SIGMAR1SMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL26939798 | 0.83 | HRH2 (0.40) | SIGMAR1MEN1KMT2ACXCR4HRH2 | |
| SCHEMBL26941832 | 0.82 | SIGMAR1 (0.36) | SIGMAR1SMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL7721322 | 0.81 | SIGMAR1 (0.44) | SIGMAR1CXCR4LTA4HHRH2HRH1 | |
| SCHEMBL26940837 | 0.81 | MEN1 (0.39) | SIGMAR1SMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL8042099 | 0.80 | SIGMAR1 (0.53) | SIGMAR1SMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL20332938 | 0.80 | CHRNA7 (0.43) | SMN1; SMN2LTA4H | |
| SCHEMBL14141934 | 0.78 | SIGMAR1 (0.47) | SIGMAR1SMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL8063 | 0.77 | SIGMAR1 (0.50) | SIGMAR1SMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL18500370 | 0.77 | ALDH1A1 (0.44) | SIGMAR1SMN1; SMN2POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018053126-A1 | INHIBITION OF BMP SIGNALING, COMPOUNDS, COMPOSITIONS AND USES THEREOF | VANDERBILT UNIVERSITY (US) | 2018-03-22 | — | — | WO | disclosed |