SCHEMBL19983772

SCHEMBL19983772

CNCc1c[nH]c2cc(Nc3ccc(Cl)cc3F)ccc12

nearest known ligand 0.48

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
GPR84 Q9NQS5 4/20 0.48
SLC6A4 P31645 3/20 0.40
CYP1A2 P05177 3/20 0.40
CYP2C8 P10632 3/20 0.40
CYP2D6 P10635 3/20 0.40
CYP2C19 P33261 3/20 0.40
CYP2C9 P11712 1/20 0.40
KCNH2 Q12809 3/20 0.39
SLC6A2 P23975 1/20 0.39
TRPA1 O75762 1/20 0.37
APP P05067 2/20 0.36
HTR2A P28223 4/20 0.36
CHRNB2 P17787 1/20 0.36
CHRNA7 P36544 1/20 0.36
CHRNA4 P43681 1/20 0.36
TRPM8 Q7Z2W7 1/20 0.36
SNCA P37840 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19984003 0.88 GPR84 (0.50) GPR84HTR2ACHRNB2CHRNA7CHRNA4
SCHEMBL19984197 0.87 GPR84 (0.49) GPR84SLC6A4CYP1A2CYP2C8CYP2D6
SCHEMBL19983754 0.87 HTR2A (0.45) GPR84APPHTR2ACHRNB2CHRNA7
SCHEMBL19983858 0.86 GPR84 (0.40) GPR84KCNH2APPHTR2ACHRNB2
SCHEMBL19983887 0.86 GPR84 (0.43) GPR84SLC6A4KCNH2SLC6A2APP
SCHEMBL19984124 0.85 GPR84 (0.42) GPR84APPHTR2ACHRNB2CHRNA7
SCHEMBL19983905 0.85 GPR84 (0.45) GPR84SLC6A4CYP1A2CYP2C8CYP2D6
SCHEMBL19984153 0.85 GPR84 (0.40) GPR84APPHTR2ACHRNB2CHRNA7
SCHEMBL19983830 0.84 HTR2A (0.48) GPR84CYP1A2HTR2ATRPM8
SCHEMBL19983711 0.84 CDK2 (0.40) GPR84SLC6A4APPHTR2ACHRNB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3052484-B1 SULFONYLINDOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME DAE WOONG PHARMA (KR) 2018-03-21 EP disclosed