Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 5/20 | 0.67 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CHUK | O15111 | 4/20 | 0.47 |
| ▸ | GABRP | O00591 | 1/20 | 0.47 |
| ▸ | GABRD | O14764 | 1/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30474111 | 1.00 | KDM5A (0.67) | KDM5ATNKS2CYP1A2CYP2C19KDM4E | |
| SCHEMBL29498328 | 0.85 | TNKS2 (0.56) | KDM5ATNKS2CYP1A2CYP2C19KDM4E | |
| SCHEMBL246359 | 0.80 | KDM5A (0.65) | KDM5AKDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL4756721 | 0.80 | KDM5A (0.65) | KDM5AKDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL30064094 | 0.80 | KDM5A (1.00) | KDM5AKDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL3242090 | 0.80 | KDM5A (1.00) | KDM5AKDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL9733532 | 0.76 | CYP1A2 (0.58) | KDM5ACYP1A2KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL14494459 | 0.76 | PDE3B (0.49) | KDM5ATNKS2CYP1A2CYP2C19KDM4E | |
| SCHEMBL26347775 | 0.75 | KDM5A (0.62) | KDM5AKDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL31338639 | 0.73 | PARP1 (0.49) | KDM5AKDM4ESMN1; SMN2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018053157-A1 | HEPATITIS B CORE PROTEIN MODULATORS | ASSEMBLY BIOSCIENCES, INC. (US) | 2018-03-22 | — | — | WO | disclosed |