Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | JUN | P05412 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18667473 | 0.90 | TP53 (0.53) | TP53MAPTSMN1; SMN2RXFP1KMT2A | |
| SCHEMBL19984599 | 0.87 | POLB (0.46) | TP53MAPTSMN1; SMN2RXFP1KMT2A | |
| SCHEMBL21291402 | 0.85 | ROCK2 (0.38) | KMT2APOLBTDP1ROCK2RAB9A | |
| SCHEMBL19984643 | 0.85 | POLB (0.45) | TP53MAPTSMN1; SMN2RXFP1KMT2A | |
| SCHEMBL19984597 | 0.84 | POLB (0.44) | TP53MAPTSMN1; SMN2RXFP1KMT2A | |
| SCHEMBL19984756 | 0.83 | ROCK2 (0.40) | TP53MAPTSMN1; SMN2RXFP1KMT2A | |
| SCHEMBL18667151 | 0.81 | TP53 (0.53) | TP53MAPTSMN1; SMN2RXFP1KMT2A | |
| SCHEMBL19984758 | 0.80 | EGLN1 (0.41) | TP53MAPTSMN1; SMN2RXFP1KMT2A | |
| SCHEMBL23018421 | 0.78 | HPGD (0.51) | TP53MAPTSMN1; SMN2RXFP1KMT2A | |
| SCHEMBL18667786 | 0.77 | ABL1 (0.42) | TP53MAPTSMN1; SMN2RXFP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018053157-A1 | HEPATITIS B CORE PROTEIN MODULATORS | ASSEMBLY BIOSCIENCES, INC. (US) | 2018-03-22 | — | — | WO | disclosed |