Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | PPIA | P62937 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13647212 | 0.81 | MAPK1 (0.46) | LMNAALDH1A1POLBL3MBTL1MAPK1 | |
| SCHEMBL2558412 | 0.76 | PPIA (0.38) | LMNAALDH1A1PPIAPOLBMAPT | |
| SCHEMBL27576279 | 0.75 | MAPT (0.42) | LMNAALDH1A1PPIAPOLBMAPT | |
| SCHEMBL392810 | 0.75 | PTPN1 (0.50) | LMNAPPIAPOLBMAPTGAA | |
| SCHEMBL8239082 | 0.75 | TSHR (0.52) | LMNAALDH1A1PPIAPOLBMAPT | |
| SCHEMBL29777919 | 0.75 | TSHR (0.52) | LMNAALDH1A1PPIAPOLBMAPT | |
| SCHEMBL12237066 | 0.74 | ALDH1A1 (0.39) | LMNAALDH1A1PPIAPOLBL3MBTL1 | |
| SCHEMBL19984929 | 0.74 | ERCC5 (0.51) | LMNAALDH1A1POLBMAPTSMN1; SMN2 | |
| SCHEMBL19984928 | 0.74 | ERCC5 (0.51) | L3MBTL1NPC1RAB9A | |
| SCHEMBL28662371 | 0.72 | TSHR (0.39) | LMNAALDH1A1PPIAPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306986-B1 | PRODRUGS AND DRUG-MACROMOLECULE CONJUGATES HAVING CONTROLLED DRUG RELEASE RATES | PROLYNX LLC (US) | 2018-03-21 | — | — | EP | disclosed |