Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.57 |
| ▸ | CES1 | P23141 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | PARP1 | P09874 | 1/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1980988 | 0.84 | CES2 (0.61) | CES2CES1KMT2APARP1CHRM2 | |
| SCHEMBL6169730 | 0.83 | CES2 (0.56) | CES2CES1KMT2APARP1CHRM2 | |
| SCHEMBL24262851 | 0.80 | CES2 (0.65) | CES2CES1KMT2APARP1CHRM2 | |
| SCHEMBL19984702 | 0.80 | HDAC3 (0.58) | CES2CES1PARP1NPC1RAB9A | |
| SCHEMBL28220977 | 0.80 | KMT2A (0.66) | CES2CES1KMT2APARP1CHRM2 | |
| SCHEMBL29815932 | 0.80 | KMT2A (0.66) | CES2CES1KMT2APARP1CHRM2 | |
| SCHEMBL11203155 | 0.80 | CES2 (0.56) | CES2CES1KMT2APARP1CHRM2 | |
| SCHEMBL11248287 | 0.80 | CES2 (0.69) | CES2CES1KMT2APARP1CHRM2 | |
| SCHEMBL30758862 | 0.80 | CES2 (0.69) | CES2CES1KMT2APARP1CHRM2 | |
| SCHEMBL7801993 | 0.79 | KMO (0.57) | CES2CES1KMT2APARP1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306986-B1 | PRODRUGS AND DRUG-MACROMOLECULE CONJUGATES HAVING CONTROLLED DRUG RELEASE RATES | PROLYNX LLC (US) | 2018-03-21 | — | — | EP | disclosed |