Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 11/20 | 0.75 |
| ▸ | PIM1 | P11309 | 9/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19986955 | 0.88 | DYRK1A (0.81) | DYRK1APIM1KCNH2 | |
| SCHEMBL22421458 | 0.88 | DYRK1A (0.81) | DYRK1APIM1KCNH2 | |
| SCHEMBL102136 | 0.84 | PIM1 (1.00) | DYRK1APIM1KCNH2 | |
| SCHEMBL140101 | 0.79 | PIM1 (1.00) | DYRK1APIM1KCNH2 | |
| SCHEMBL102861 | 0.79 | PIM1 (1.00) | DYRK1APIM1KCNH2 | |
| SCHEMBL19987030 | 0.79 | PIM1 (0.78) | PIM1KCNH2 | |
| SCHEMBL14653586 | 0.79 | DYRK1A (0.73) | DYRK1APIM1 | |
| SCHEMBL15699138 | 0.79 | DYRK1A (0.76) | DYRK1APIM1 | |
| SCHEMBL102421 | 0.78 | DYRK1A (0.91) | DYRK1APIM1 | |
| SCHEMBL19986921 | 0.77 | PIM1 (0.79) | PIM1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3812387-A1 | HETEROCYCLIC PROTEIN KINASE INHIBITORS | Sumitomo Dainippon Pharma Oncology, Inc. (US) | 2021-04-28 | — | — | EP | disclosed |
| EP-3409278-B1 | HETEROCYCLIC PROTEIN KINASE INHIBITORS | TOLERO PHARMACEUTICALS INC (US) | 2020-09-16 | — | — | EP | disclosed |
| EP-2734205-B1 | HETEROCYCLIC PROTEIN KINASE INHIBITORS | TOLERO PHARMACEUTICALS INC (US) | 2018-03-21 | — | — | EP | disclosed |