Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19539757 | 0.88 | TSHR (0.52) | RAB9ATSHRALDH1A1NPC1TP53 | |
| SCHEMBL23336386 | 0.84 | TSHR (0.49) | RAB9ATSHRALDH1A1NPC1TP53 | |
| SCHEMBL10554268 | 0.81 | TSHR (0.56) | RAB9ATSHRALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL18909735 | 0.80 | L3MBTL1 (0.46) | RAB9ATSHRALDH1A1NPC1TP53 | |
| SCHEMBL20798796 | 0.78 | MEN1 (0.43) | RAB9ATSHRALDH1A1NPC1TP53 | |
| SCHEMBL19987074 | 0.78 | TSHR (0.44) | RAB9ATSHRALDH1A1NPC1TP53 | |
| SCHEMBL19662739 | 0.76 | RAB9A (0.45) | RAB9ATSHRALDH1A1NPC1TP53 | |
| SCHEMBL21298991 | 0.76 | RAB9A (0.44) | RAB9ATSHRALDH1A1NPC1TP53 | |
| SCHEMBL12548927 | 0.74 | L3MBTL1 (0.55) | TSHRALDH1A1SMN1; SMN2KMT2AATM | |
| SCHEMBL1332332 | 0.74 | L3MBTL1 (0.55) | TSHRALDH1A1SMN1; SMN2KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2734205-B1 | HETEROCYCLIC PROTEIN KINASE INHIBITORS | TOLERO PHARMACEUTICALS INC (US) | 2018-03-21 | — | — | EP | disclosed |