SCHEMBL19987891

SCHEMBL19987891

O=C(O)Cc1cc(-c2ccc(F)cc2)ccc1F

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP1 P03956 1/20 0.50
MMP2 P08253 1/20 0.50
MMP3 P08254 1/20 0.50
MMP9 P14780 1/20 0.50
MMP12 P39900 1/20 0.50
MMP13 P45452 1/20 0.50
MMP14 P50281 1/20 0.50
BCL2L1 Q07817 1/20 0.46
BAD Q92934 1/20 0.46
TSHR P16473 2/20 0.44
HTT P42858 2/20 0.44
FABP4 P15090 1/20 0.43
FABP5 Q01469 1/20 0.43
LMNA P02545 2/20 0.43
CXCL8 P10145 1/20 0.42
PTGER2 P43116 1/20 0.42
RXRA P19793 3/20 0.42
RXRB P28702 3/20 0.42
RXRG P48443 3/20 0.42
PTGS1 P23219 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27717138 0.89 PTGS1 (0.53) MMP1MMP2MMP3MMP9MMP12
SCHEMBL31147931 0.86 MMP1 (0.50) MMP1MMP2MMP3MMP9MMP12
SCHEMBL29471363 0.85 TSHR (0.53) MMP1MMP2MMP3MMP9MMP12
SCHEMBL503667 0.85 TSHR (0.53) MMP1MMP2MMP3MMP9MMP12
SCHEMBL11023467 0.84 MMP1 (0.49) MMP1MMP2MMP3MMP9MMP12
SCHEMBL508733 0.83 RXRA (0.49) MMP1MMP2MMP3MMP9MMP12
SCHEMBL27907587 0.81 MMP1 (0.47) MMP1MMP2MMP3MMP9MMP12
SCHEMBL29459931 0.77 TSHR (0.53) TSHRCXCL8
SCHEMBL503325 0.77 TSHR (0.53) TSHRCXCL8
Bromide SCHEMBL8397120 0.76 TSHR (0.51) TSHRCXCL8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3298639-A1 FORMULATION CONTAINING AN ORGANIC SEMICONDUCTOR AND A METAL COMPLEX Merck Patent GmbH (DE) 2018-03-28 EP disclosed