Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ANPEP | P15144 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11890516 | 1.00 | TSHR (0.35) | TSHRMAPK1ALDH1A1ANPEPCYP2C19 | |
| SCHEMBL11890518 | 1.00 | TSHR (0.35) | TSHRMAPK1ALDH1A1ANPEPCYP2C19 | |
| SCHEMBL11990752 | 0.79 | TSHR (0.50) | TSHRMAPK1ALDH1A1ANPEPCYP2C19 | |
| SCHEMBL13010229 | 0.79 | TSHR (0.50) | TSHRMAPK1ALDH1A1ANPEPCYP2C19 | |
| SCHEMBL22623946 | 0.79 | TSHR (0.50) | TSHRMAPK1ALDH1A1ANPEPCYP2C19 | |
| SCHEMBL17163926 | 0.79 | TSHR (0.33) | TSHRMAPK1ALDH1A1ANPEPCYP2C19 | |
| SCHEMBL31544636 | 0.76 | MAPK1 (0.37) | TSHRMAPK1CYP2C19 | |
| SCHEMBL10026572 | 0.74 | MEN1 (0.33) | TSHRALDH1A1 | |
| SCHEMBL14417057 | 0.74 | TSHR (0.33) | TSHRMAPK1ALDH1A1 | |
| SCHEMBL25954457 | 0.74 | TSHR (0.33) | TSHRMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0474284-A1 | Method for modifying the permeability of an underground formation | Akzo Nobel N.V. (NL) | 1992-03-11 | — | — | EP | claimed |
| CN-110157538-B | Waste oil treatment based on green solvent | 中国人民解放军陆军勤务学院 | 2022-08-23 | — | — | CN | disclosed |
| US-9586931-B2 | Triazolyl derivatives as Syk inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-03-07 | — | — | US | disclosed |
| US-20150239866-A1 | TRIAZOLYL DERIVATIVES AS SYK INHIBITORS | MERCK CANADA INC. (CA) | 2015-08-27 | — | — | US | disclosed |
| US-9079890-B2 | Intermediates for the preparation of pyridin-2-yl-amino-1,2,4-thiadiazole derivatives | ARRAY BIOPHARMA INC. (US) | 2015-07-14 | — | — | US | disclosed |
| US-20150057448-A1 | INTERMEDIATES FOR THE PREPARATION OF PYRIDIN-2-YL-AMINO-1,2,4-THIADIAZOLE DERIVATIVES | ARRAY BIOPHARMA, INC. | 2015-02-26 | — | — | US | disclosed |
| US-8853409-B2 | Pyridin-2yl-amino-1, 2, 4-thiadiazole derivatives as glucokinase activators for the treatment of diabetes mellitus | ARRAY BIOPHARMA INC. (US) | 2014-10-07 | — | — | US | disclosed |
| US-20120277242-A1 | Pyridin-2YL-Amino-1, 2, 4-Thiadiazole Derivatives as Glucokinase Activators for the Treatment of Diabetes Mellitus | ARRAY BIOPHARMA, INC. (US) | 2012-11-01 | — | — | US | disclosed |
| US-20120277242-A1 | Pyridin-2YL-Amino-1, 2, 4-Thiadiazole Derivatives as Glucokinase Activators for the Treatment of Diabetes Mellitus | ARRAY BIOPHARMA, INC. (US) | 2012-11-01 | — | — | US | disclosed |
| US-8212045-B2 | Pyridin-2-yl-amino-1, 2, 4-thiadiazole derivatives as glucokinase activators for the treatment of diabetes mellitus | ARRAY BIOPHARMA, INC. (US) | 2012-07-03 | — | — | US | disclosed |
| US-20040010967-A1 | Friction modifier alkoxyamine salts of carboxylic acids as additives for fuel compositions and methods of use thereof | AFTON CHEMICAL INTANGIBLES LLC | 2004-01-22 | — | — | US | disclosed |
| US-20030200697-A1 | Friction modifier additives for fuel compositions and methods of use thereof | AFTON CHEMICAL INTANGIBLES LLC | 2003-10-30 | — | — | US | disclosed |
| EP-1357170-A2 | Friction modifier additives for fuel compositions and methods of use thereof | ETHYL CORPORATION (US) | 2003-10-29 | — | — | EP | disclosed |
| CN-1110541-C | Concentrated water-dispersible stable fiber softener compositions | PROCTER & GAMBLE (US) | 2003-06-04 | — | — | CN | disclosed |
| US-6277158-B1 | COMBUSTIBLE FUEL CONTAINING FUEL ADDITIVES SUCH AD ASHLESS FRICITION MODIFIER LIKE N-BUTYL AMINE OLEATE, TALL OIL FATTY ACIDS, DEPOSIT INHIBITOR AND CARRIER FLUID | EXXON RESEARCH AND ENGINEERING COMPANY | 2001-08-21 | — | — | US | disclosed |
| CN-1219953-A | Fabric softening compound/composition | PROCTER & GAMBLE (US) | 1999-06-16 | — | — | CN | disclosed |
| CN-1196082-A | Concentrated stable fabric softening compositions comprising chelants | PROCTER & GAMBLE (US) | 1998-10-14 | — | — | CN | disclosed |
| EP-0839179-A1 | CONCENTRATED, WATER DISPERSIBLE, STABLE, FABRIC SOFTENING COMPOSITIONS | THE PROCTER & GAMBLE COMPANY (US) | 1998-05-06 | — | — | EP | disclosed |
| US-5747443-A | BIODEGRADABLE QUATERNARY AMMONIUM COMPOUNDS | THE PROCTER & GAMBLE COMPANY (US) | 1998-05-05 | — | — | US | disclosed |
| WO-1997003170-A1 | CONCENTRATED, WATER DISPERSIBLE, STABLE, FABRIC SOFTENING COMPOSITIONS | THE PROCTER & GAMBLE COMPANY (US) | 1997-01-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150239866-A1 | TRIAZOLYL DERIVATIVES AS SYK INHIBITORS | SYK, BTK, TYRO3 | TSHR 1340/4885MAPK1 652/4885ALDH1A1 3298/4885 |
| US-20120277242-A1 | Pyridin-2YL-Amino-1, 2, 4-Thiadiazole Derivatives as Glucokinase Activators for the Treatment of Diabetes Mellitus | PDXK, GCKR, GCK | TSHR 1257/4885MAPK1 939/4885ALDH1A1 1019/4885 |
| US-20150057448-A1 | INTERMEDIATES FOR THE PREPARATION OF PYRIDIN-2-YL-AMINO-1,2,4-THIADIAZOLE DERIVATIVES | PDXK, IL4I1, CDK2 | TSHR 1180/4885MAPK1 1443/4885ALDH1A1 337/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.