Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MBOAT4 | Q96T53 | 12/20 | 0.76 |
| ▸ | ITGB3 | P05106 | 6/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18162647 | 1.00 | MBOAT4 (0.76) | MBOAT4ITGB3ITGA2BHRH3 | |
| SCHEMBL20012969 | 0.90 | MBOAT4 (0.63) | MBOAT4ITGB3ITGA2BHRH3 | |
| SCHEMBL19971818 | 0.89 | MBOAT4 (0.68) | MBOAT4ITGB3ITGA2BHRH3 | |
| SCHEMBL19971817 | 0.89 | MBOAT4 (0.68) | MBOAT4ITGB3ITGA2BHRH3 | |
| SCHEMBL18162648 | 0.87 | MBOAT4 (1.00) | MBOAT4HRH3 | |
| SCHEMBL19991517 | 0.87 | MBOAT4 (1.00) | MBOAT4HRH3 | |
| SCHEMBL19991548 | 0.86 | MBOAT4 (1.00) | MBOAT4ITGB3ITGA2B | |
| SCHEMBL18162678 | 0.86 | MBOAT4 (1.00) | MBOAT4ITGB3ITGA2B | |
| SCHEMBL18162679 | 0.86 | MBOAT4 (0.72) | MBOAT4ITGB3ITGA2BHRH3 | |
| SCHEMBL19991529 | 0.86 | MBOAT4 (0.72) | MBOAT4ITGB3ITGA2BHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3283473-B1 | GHRELIN O-ACYL TRANSFERASE INHIBITORS | LILLY CO ELI (US) | 2019-01-02 | — | — | EP | disclosed |
| US-10093651-B2 | Ghrelin O-acyl transferase inhibitors | ELI LILLY AND COMPANY (US) | 2018-10-09 | — | — | US | disclosed |
| US-20180086732-A1 | GHRELIN 0-ACYL TRANSFERASE INHIBITORS | ELI LILLY AND COMPANY | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180086732-A1 | GHRELIN 0-ACYL TRANSFERASE INHIBITORS | MBOAT4, GIPR, PLAAT2 | MBOAT4 1/4885ITGB3 4128/4885ITGA2B 3681/4885 |
| US-10093651-B2 | Ghrelin O-acyl transferase inhibitors | MBOAT4, GIPR, DGAT1 | MBOAT4 1/4885ITGB3 3850/4885ITGA2B 3269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.