Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOXO1 | Q8NFA2 | 1/20 | 0.54 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.45 |
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.45 |
| ▸ | F2 | P00734 | 2/20 | 0.45 |
| ▸ | PLG | P00747 | 2/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.44 |
| ▸ | LYPLA2 | O95372 | 1/20 | 0.44 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.44 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.44 |
| ▸ | TXK | P42681 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | GBA1 | P04062 | 1/20 | 0.44 |
| ▸ | TLR2 | O60603 | 1/20 | 0.43 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL19991675 | 0.91 | NOXO1 (0.55) | NOXO1PRSS1PRSS2PRSS3TPSAB1 | |
| Trifluoroacetic Acid SCHEMBL30606899 | 0.91 | NOXO1 (0.55) | NOXO1PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL18081133 | 0.91 | NOXO1 (0.58) | NOXO1PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL18038688 | 0.81 | PBRM1 (0.44) | — | |
| SCHEMBL28650244 | 0.76 | PBRM1 (0.46) | — | |
| SCHEMBL20161403 | 0.74 | CA12 (0.60) | NOXO1PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL20161540 | 0.74 | F2 (0.62) | NOXO1PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL23365942 | 0.73 | CA12 (0.58) | NOXO1PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL23365946 | 0.73 | CA12 (0.58) | NOXO1PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL23365917 | 0.73 | F2 (0.63) | NOXO1PRSS1PRSS2PRSS3TPSAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3262036-B1 | THERAPEUTIC PYRIDAZINE COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2023-09-13 | — | — | EP | disclosed |
| US-10308614-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2019-06-04 | — | — | US | disclosed |
| US-20180086720-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10308614-B2 | Therapeutic compounds and uses thereof | SMARCC1, SMARCC2, SMARCA4 | NOXO1 3566/4885PRSS1 2220/4885PRSS2 2251/4885 |
| US-20180086720-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | SMARCC1, SMARCC2, SMARCA4 | NOXO1 3566/4885PRSS1 2220/4885PRSS2 2251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.