Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOXO1 | Q8NFA2 | 1/20 | 0.55 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.47 |
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.47 |
| ▸ | PLG | P00747 | 2/20 | 0.47 |
| ▸ | F2 | P00734 | 2/20 | 0.47 |
| ▸ | GBA1 | P04062 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.45 |
| ▸ | LYPLA2 | O95372 | 1/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 7/20 | 0.44 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL19991675 | 1.00 | NOXO1 (0.55) | NOXO1PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL18081133 | 0.96 | NOXO1 (0.58) | NOXO1PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL19991674 | 0.91 | NOXO1 (0.54) | NOXO1PRSS1PRSS2PRSS3TPSAB1 | |
| Trifluoroacetic Acid SCHEMBL18038686 | 0.81 | PBRM1 (0.54) | — | |
| Trifluoroacetic Acid SCHEMBL30606983 | 0.79 | PBRM1 (0.58) | — | |
| Trifluoroacetic Acid SCHEMBL28663569 | 0.79 | PBRM1 (0.58) | — | |
| Trifluoroacetic Acid SCHEMBL28650245 | 0.76 | PBRM1 (0.55) | — | |
| Trifluoroacetic Acid SCHEMBL1163788 | 0.75 | PRSS1 (0.63) | PRSS1PRSS2PRSS3TPSAB1PLG | |
| Trifluoroacetic Acid SCHEMBL2520452 | 0.75 | PRSS1 (0.63) | PRSS1PRSS2PRSS3TPSAB1PLG | |
| SCHEMBL20161403 | 0.75 | CA12 (0.60) | NOXO1PRSS1PRSS2PRSS3TPSAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3262036-B1 | THERAPEUTIC PYRIDAZINE COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2023-09-13 | — | — | EP | disclosed |