Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 9/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 9/20 | 0.35 |
| ▸ | PARP1 | P09874 | 8/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.32 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.32 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | CLK1 | P49759 | 1/20 | 0.30 |
| ▸ | CLK2 | P49760 | 1/20 | 0.30 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.30 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19992155 | 0.82 | PARP1 (0.49) | TNKSTNKS2PARP1PARP2PARP3 | |
| SCHEMBL16310700 | 0.67 | PIK3CD (0.38) | PIK3CDPIK3R1 | |
| SCHEMBL16578756 | 0.65 | FASN (0.36) | PARP1PARP2PARP3KDM4E | |
| SCHEMBL16309057 | 0.63 | PIK3CD (0.35) | PIK3CDPIK3R1 | |
| SCHEMBL19992165 | 0.62 | PARP1 (0.57) | TNKSTNKS2PARP1PARP2PARP3 | |
| SCHEMBL26017922 | 0.59 | TNKS (0.48) | TNKSTNKS2PARP1PARP2PARP3 | |
| SCHEMBL20404208 | 0.58 | PARP1 (0.64) | TNKSTNKS2PARP1KDM4E | |
| SCHEMBL16858459 | 0.58 | KDM4E (0.44) | PARP1KDM4ERXFP1 | |
| SCHEMBL30753031 | 0.57 | UPP1 (0.43) | TNKSTNKS2PARP1KDM4E | |
| SCHEMBL17570611 | 0.57 | TRPV4 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3008053-B1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD CALISTOGA LLC (US) | 2018-03-21 | — | — | EP | disclosed |