Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 10/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12897882 | 0.86 | OPRL1 (0.46) | OPRL1OPRM1KCNH2DRD2SLC6A4 | |
| SCHEMBL16951709 | 0.85 | OPRL1 (0.59) | OPRL1OPRM1KCNH2SLC6A4 | |
| SCHEMBL4975027 | 0.84 | GRM2 (0.47) | OPRL1DRD2SLC6A4KMT2AESR1 | |
| SCHEMBL17642598 | 0.82 | QDPR (0.42) | DRD2SLC6A4KMT2A | |
| SCHEMBL4972924 | 0.81 | OPRL1 (0.51) | OPRL1DRD2SLC6A4KMT2AESR1 | |
| SCHEMBL21009648 | 0.80 | ALDH1A1 (0.48) | DRD2 | |
| SCHEMBL6967140 | 0.79 | OPRL1 (0.51) | OPRL1OPRM1KCNH2DRD2SLC6A4 | |
| SCHEMBL28506474 | 0.79 | QDPR (0.40) | OPRL1OPRM1KCNH2KMT2A | |
| SCHEMBL10819369 | 0.79 | QDPR (0.56) | OPRL1DRD2SLC6A4KMT2AESR1 | |
| SCHEMBL522141 | 0.79 | HTR1D (0.56) | KMT2AESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2927214-B1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND | KYOWA HAKKO KIRIN CO LTD (JP) | 2018-03-21 | — | — | EP | disclosed |