Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3
The experimentally established mechanism targets of Epinephrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 7/20 | 0.79 |
| ▸ | ADRB1 known ✓ | P08588 | 5/20 | 0.77 |
| ▸ | ADRB3 known ✓ | P13945 | 4/20 | 0.77 |
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.77 |
| ▸ | ADRA2B known ✓ | P18089 | 2/20 | 0.77 |
| ▸ | ADRA2C known ✓ | P18825 | 2/20 | 0.77 |
| ▸ | ADRA1D known ✓ | P25100 | 2/20 | 0.77 |
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 0.77 |
| ▸ | ADRA1B known ✓ | P35368 | 2/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.79 |
| ▸ | BLM | P54132 | 6/20 | 0.79 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.79 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.79 |
| ▸ | TDP1 | Q9NUW8 | 8/20 | 0.77 |
| ▸ | MAPT | P10636 | 7/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.77 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.77 |
| ▸ | MEN1 | O00255 | 4/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.77 |
| ▸ | TSHR | P16473 | 4/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Racepinephrine SCHEMBL9614373 | 0.89 | KDM4E (1.00) | KDM4EADRB2BLMPMP22NPSR1 | |
| Racepinephrine SCHEMBL41370 | 0.89 | KDM4E (1.00) | KDM4EADRB2BLMPMP22NPSR1 | |
| Epinephrine SCHEMBL25041 | 0.89 | KDM4E (1.00) | KDM4EADRB2BLMPMP22NPSR1 | |
| Racepinephrine SCHEMBL31238229 | 0.89 | KDM4E (1.00) | KDM4EADRB2BLMPMP22NPSR1 | |
| Epinephrine SCHEMBL31267207 | 0.89 | KDM4E (1.00) | KDM4EADRB2BLMPMP22NPSR1 | |
| Epinephrine SCHEMBL4980185 | 0.89 | KDM4E (1.00) | KDM4EADRB2BLMPMP22NPSR1 | |
| L-Adrenaline SCHEMBL4983607 | 0.89 | KDM4E (1.00) | KDM4EADRB2BLMPMP22NPSR1 | |
| Racepinephrine SCHEMBL16667632 | 0.89 | KDM4E (1.00) | KDM4EADRB2BLMPMP22NPSR1 | |
| Epinephrine SCHEMBL3111795 | 0.88 | KDM4E (0.96) | KDM4EADRB2BLMPMP22NPSR1 | |
| Racepinephrine SCHEMBL28311143 | 0.88 | KDM4E (0.96) | KDM4EADRB2BLMPMP22NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515520-B1 | DEVICES AND METHODS FOR VASCULAR HYPERPERFUSION OF EXTRAVASCULAR SPACE | ALL VASCULAR PTY LTD (AU) | 2024-03-06 | — | — | EP | disclosed |
| US-20200038575-A1 | Devices and Methods for Vascular Hyperperfusion of Extravascular Space | All Vascular Pty Limited (AU) | 2020-02-06 | — | — | US | disclosed |
| EP-3515520-A1 | DEVICES AND METHODS FOR VASCULAR HYPERPERFUSION OF EXTRAVASCULAR SPACE | All Vascular Pty Limited (AU) | 2019-07-31 | — | — | EP | disclosed |
| WO-2018053574-A1 | DEVICES AND METHODS FOR VASCULAR HYPERPERFUSION OF EXTRAVASCULAR SPACE | All Vascular Pty Limited (AU) | 2018-03-29 | — | — | WO | disclosed |