Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19995293 | 0.77 | KDM4E (1.00) | KDM4EHTTKMT2AALDH1A1HSD17B10 | |
| SCHEMBL23378741 | 0.59 | HCRTR1 (0.52) | KDM4EHTTKMT2AABL1RIN1 | |
| SCHEMBL8871046 | 0.59 | MAPT (0.67) | KDM4EHTTKMT2AALDH1A1HSD17B10 | |
| SCHEMBL24430062 | 0.59 | NPC1 (0.77) | KDM4EKMT2AALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL6026955 | 0.58 | NPC1 (0.62) | KDM4EKMT2AALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL1101337 | 0.58 | KDM4E (0.68) | KDM4EHTTALDH1A1HSD17B10SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9052016 | 0.58 | NPC1 (0.61) | KDM4EKMT2AALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL10368023 | 0.58 | RAB9A (0.48) | KDM4EKMT2ASMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL9050436 | 0.57 | MCHR1 (0.57) | KDM4EHTTKMT2ASMN1; SMN2LMNA | |
| SCHEMBL9284192 | 0.57 | MAPT (0.68) | KDM4EHTTKMT2AALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515435-A1 | WASP-PROTECTING SMALL MOLECULES, COMPOSITIONS, METHODS AND USES THEREOF IN THE TREATMENT OF INNATE AND ACQUIRED IMMUNE-RELATED DISORDERS OR CONDITIONS | Bar-Ilan University (IL) | 2019-07-31 | — | — | EP | disclosed |
| WO-2018055627-A1 | WASP-PROTECTING SMALL MOLECULES, COMPOSITIONS, METHODS AND USES THEREOF IN THE TREATMENT OF INNATE AND ACQUIRED IMMUNE-RELATED DISORDERS OR CONDITIONS | BAR ILAN UNIVERSITY (IL) | 2018-03-29 | — | — | WO | disclosed |