Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
| ▸ | TUBB | P07437 | 1/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.34 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.34 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.34 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.34 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.34 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.34 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.34 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.34 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19995503 | 0.85 | PGGT1B (0.37) | JAK3NR1H2NR1H3KMT2AALDH1A1 | |
| SCHEMBL19995494 | 0.84 | ATR (0.36) | ATRJAK3NR1H2NR1H3MEN1 | |
| SCHEMBL18096349 | 0.80 | MAP4K4 (0.36) | JAK3NR1H2NR1H3MEN1KMT2A | |
| SCHEMBL18096155 | 0.80 | MAP4K4 (0.42) | JAK3NR1H2NR1H3KIF18ASPR | |
| SCHEMBL19995483 | 0.77 | RET (0.38) | JAK3NR1H2NR1H3KMT2AHDAC1 | |
| SCHEMBL19096978 | 0.76 | NR1H2 (0.43) | NR1H2NR1H3MEN1KMT2AMAPT | |
| SCHEMBL17385177 | 0.76 | NR1H2 (0.43) | NR1H2NR1H3MEN1KMT2AMAPT | |
| SCHEMBL20000451 | 0.75 | CRBN (0.49) | JAK3NR1H2NR1H3KIF18AHDAC1 | |
| SCHEMBL30686573 | 0.74 | MAP4K4 (0.37) | JAK3NR1H2NR1H3MEN1KMT2A | |
| SCHEMBL38666134 | 0.73 | MEN1 (0.39) | JAK3NR1H2NR1H3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018057588-A1 | FURO[3,2-B]PYRIDINE COMPOUNDS USEFUL AS INHIBITORS OF THE PAR-2 SIGNALING PATHWAY | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2018-03-29 | — | — | WO | disclosed |