Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | OGA | O60502 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | CKS1B | P61024 | 2/20 | 0.39 |
| ▸ | SKP1 | P63208 | 2/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | RBP4 | P02753 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18096096 | 0.89 | CYP1A2 (0.45) | CRBNNR1H2NR1H3CKS1BSKP1 | |
| SCHEMBL30686573 | 0.82 | MAP4K4 (0.37) | NR1H2NR1H3CKS1BSKP1SKP2 | |
| SCHEMBL18096155 | 0.81 | MAP4K4 (0.42) | NR1H2NR1H3CKS1BSKP1SKP2 | |
| SCHEMBL19995494 | 0.81 | ATR (0.36) | NR1H2NR1H3CKS1BSKP1SKP2 | |
| SCHEMBL18096349 | 0.81 | MAP4K4 (0.36) | NR1H2NR1H3CKS1BSKP1SKP2 | |
| SCHEMBL25279825 | 0.81 | NR1H2 (0.40) | HRH3NR1H2NR1H3CKS1BSKP1 | |
| SCHEMBL18096385 | 0.80 | CRBN (0.42) | CRBNHRH3OGANR1H2NR1H3 | |
| SCHEMBL19995483 | 0.79 | RET (0.38) | NR1H2NR1H3HDAC1GPR119MAP4K4 | |
| SCHEMBL18096314 | 0.79 | GPR119 (0.57) | NR1H2NR1H3GPR119 | |
| SCHEMBL25738415 | 0.79 | GPR119 (0.45) | HRH3NR1H2NR1H3CKS1BSKP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018057588-A1 | FURO[3,2-B]PYRIDINE COMPOUNDS USEFUL AS INHIBITORS OF THE PAR-2 SIGNALING PATHWAY | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2018-03-29 | — | — | WO | disclosed |