Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.35 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.34 |
| ▸ | CKS1B | P61024 | 2/20 | 0.33 |
| ▸ | SKP1 | P63208 | 2/20 | 0.33 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.33 |
| ▸ | PGK1 | P00558 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18096349 | 0.88 | MAP4K4 (0.36) | MAP4K4NR1H2NR1H3SUV39H2HDAC1 | |
| SCHEMBL18096155 | 0.88 | MAP4K4 (0.42) | MAP4K4NR1H2NR1H3HDAC1NTRK1 | |
| SCHEMBL19995483 | 0.85 | RET (0.38) | MAP4K4NR1H2NR1H3HDAC1NTRK1 | |
| SCHEMBL19995473 | 0.84 | ATR (0.36) | ATRPOLBNR1H2NR1H3HDAC1 | |
| SCHEMBL30686573 | 0.82 | MAP4K4 (0.37) | MAP4K4NR1H2NR1H3HDAC1NTRK1 | |
| SCHEMBL20000451 | 0.81 | CRBN (0.49) | MAP4K4NR1H2NR1H3HDAC1NTRK1 | |
| SCHEMBL16333395 | 0.80 | POLB (0.40) | MAP4K4POLBNR1H2NR1H3SUV39H2 | |
| SCHEMBL19995503 | 0.77 | PGGT1B (0.37) | NR1H2NR1H3KMT2AJAK3 | |
| SCHEMBL18096261 | 0.77 | MAPT (0.39) | NR1H2NR1H3HDAC1NTRK1MAPT | |
| SCHEMBL17385177 | 0.76 | NR1H2 (0.43) | NR1H2NR1H3MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018057588-A1 | FURO[3,2-B]PYRIDINE COMPOUNDS USEFUL AS INHIBITORS OF THE PAR-2 SIGNALING PATHWAY | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2018-03-29 | — | — | WO | disclosed |