Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 13/20 | 0.53 |
| ▸ | LPL | P06858 | 12/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.51 |
| ▸ | F11 | P03951 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.45 |
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | CA9 | Q16790 | 3/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA3 | P07451 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA6 | P23280 | 1/20 | 0.45 |
| ▸ | CA5A | P35218 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.45 |
| ▸ | P4HB | P07237 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14694622 | 0.86 | LIPG (0.52) | LIPGLPLESR2F11CA1 | |
| SCHEMBL24774874 | 0.86 | LIPG (0.52) | LIPGLPLESR2F11CA1 | |
| SCHEMBL24775237 | 0.86 | LIPG (0.52) | LIPGLPLESR2F11CA1 | |
| SCHEMBL25648947 | 0.85 | LPL (0.50) | LIPGLPLESR2F11CA1 | |
| SCHEMBL28371250 | 0.83 | LIPG (0.57) | LIPGLPLESR2F11CA1 | |
| SCHEMBL15774946 | 0.83 | LIPG (0.49) | LIPGLPLESR2F11CA1 | |
| SCHEMBL228212 | 0.82 | LPL (0.71) | LIPGLPLESR2F11CA1 | |
| SCHEMBL4508180 | 0.82 | LPL (0.50) | LIPGLPLESR2F11CA1 | |
| SCHEMBL31376528 | 0.82 | ESR2 (0.50) | LIPGLPLESR2F11CA1 | |
| SCHEMBL15774823 | 0.82 | LPL (0.47) | LIPGLPLESR2F11CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023110936-A1 | REVERSIBLE MACROCYCLIC KINASE INHIBITORS | NETHERLANDS TRANSLATIONAL RESEARCH CENTER HOLDING B.V (NL) | 2023-06-22 | — | — | WO | disclosed |
| US-9926314-B2 | Compounds and compositions for the treatment of parasitic diseases | NOVARTIS AG (CH) | 2018-03-27 | — | — | US | disclosed |