Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 5/20 | 0.40 |
| ▸ | CA1 | P00915 | 5/20 | 0.40 |
| ▸ | CA2 | P00918 | 5/20 | 0.40 |
| ▸ | CA9 | Q16790 | 5/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.38 |
| ▸ | SPR | P35270 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 2/20 | 0.35 |
| ▸ | CA7 | P43166 | 2/20 | 0.35 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17949180 | 0.94 | TRPV1 (0.44) | CA12CA1CA2CA9TRPV1 | |
| SCHEMBL17942345 | 0.89 | CA12 (0.38) | CA12CA1CA2CA9TRPV1 | |
| SCHEMBL17949197 | 0.89 | TRPV1 (0.46) | CA12CA1CA2CA9TRPV1 | |
| SCHEMBL30833479 | 0.87 | CA12 (0.37) | CA12CA1CA2CA9TRPV1 | |
| SCHEMBL17942348 | 0.87 | CA12 (0.37) | CA12CA1CA2CA9TRPV1 | |
| SCHEMBL17949411 | 0.87 | TRPV1 (0.44) | CA12CA1CA2CA9TRPV1 | |
| SCHEMBL17949353 | 0.86 | RORC (0.41) | TRPV1EPHX2RORCSPRNAMPT | |
| SCHEMBL29529714 | 0.86 | RORC (0.41) | TRPV1EPHX2RORCSPRNAMPT | |
| SCHEMBL19996438 | 0.85 | EPHX2 (0.37) | CA12CA1CA2CA9TRPV1 | |
| SCHEMBL29529611 | 0.85 | JAK2 (0.41) | CA12CA1CA2CA9TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9925177-B2 | 4-methylsulfonyl-substituted piperidine urea compounds | MyoKardia, Inc. (US) | 2018-03-27 | — | — | US | disclosed |