Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 2/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.39 |
| ▸ | PTGDR | Q13258 | 3/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20248011 | 0.85 | ENPP2 (0.70) | ENPP2HDAC6HDAC1HDAC4HDAC2 | |
| SCHEMBL20248008 | 0.84 | HDAC6 (0.43) | ENPP2HDAC6HDAC1HDAC4HDAC2 | |
| SCHEMBL16750279 | 0.84 | ENPP2 (0.75) | ENPP2HDAC6HDAC1HDAC4HDAC2 | |
| SCHEMBL20248012 | 0.84 | ENPP2 (0.65) | ENPP2HDAC6HDAC1HDAC4HDAC2 | |
| SCHEMBL20248014 | 0.83 | ENPP2 (0.55) | ENPP2HDAC6HDAC1HDAC4HDAC2 | |
| SCHEMBL20206465 | 0.79 | ENPP2 (0.53) | ENPP2HDAC6HDAC1HDAC4HDAC2 | |
| SCHEMBL19996789 | 0.76 | ENPP2 (0.58) | ENPP2HDAC6HDAC1HDAC4HDAC2 | |
| SCHEMBL19996787 | 0.75 | ENPP2 (0.68) | ENPP2HDAC6HDAC1HDAC4HDAC2 | |
| SCHEMBL20248013 | 0.73 | ENPP2 (0.52) | ENPP2HDAC6HDAC1HDAC4HDAC2 | |
| SCHEMBL16750265 | 0.73 | ENPP2 (0.85) | ENPP2HDAC6HDAC1HDAC4HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9926318-B2 | Tetracyclic autotaxin inhibitors | PHARMAKEA, INC. (US) | 2018-03-27 | — | — | US | disclosed |