Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.35 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.35 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.35 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20248012 | 0.89 | ENPP2 (0.65) | ENPP2HDAC6HDAC4HDAC1HDAC2 | |
| SCHEMBL20248011 | 0.84 | ENPP2 (0.70) | ENPP2HDAC6HDAC4HDAC1HDAC2 | |
| SCHEMBL16750334 | 0.84 | ENPP2 (0.72) | ENPP2HDAC6HDAC4HDAC1HDAC2 | |
| SCHEMBL18070808 | 0.76 | ENPP2 (0.61) | ENPP2HDAC6HDAC4HDAC1HDAC2 | |
| SCHEMBL16750335 | 0.74 | ENPP2 (0.53) | ENPP2HDAC6HDAC4HDAC1HDAC2 | |
| SCHEMBL20248018 | 0.74 | ENPP2 (0.47) | ENPP2HDAC6HDAC4HDAC1HDAC2 | |
| SCHEMBL20248014 | 0.73 | ENPP2 (0.55) | ENPP2HDAC6HDAC4HDAC1HDAC2 | |
| SCHEMBL19996766 | 0.73 | ENPP2 (0.55) | ENPP2HDAC6HDAC4HDAC1HDAC2 | |
| SCHEMBL16750324 | 0.73 | ENPP2 (0.45) | ENPP2HDAC6HDAC1KDM4ETBXA2R | |
| SCHEMBL20206465 | 0.73 | ENPP2 (0.53) | ENPP2HDAC6HDAC4HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180162859-A1 | TETRACYCLIC AUTOTAXIN INHIBITORS | ATXCO, INC. | 2018-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180162859-A1 | TETRACYCLIC AUTOTAXIN INHIBITORS | ENPP2, SERPINB1, UACA | ENPP2 1/4885HDAC6 195/4885HDAC4 1646/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.