Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 7/20 | 0.57 |
| ▸ | METAP2 | P50579 | 7/20 | 0.57 |
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | RAB9A | P51151 | 5/20 | 0.57 |
| ▸ | PKM | P14618 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | MTOR | P42345 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | CBFB | Q13951 | 13/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29994214 | 0.83 | METAP2 (0.61) | METAP1METAP2NPC1RAB9APKM | |
| SCHEMBL32660737 | 0.83 | CBFB (0.80) | METAP1METAP2NPC1RAB9APKM | |
| SCHEMBL125118 | 0.83 | CBFB (0.80) | METAP1METAP2NPC1RAB9APKM | |
| SCHEMBL124343 | 0.83 | CBFB (0.80) | METAP1METAP2NPC1RAB9APKM | |
| SCHEMBL13675150 | 0.83 | CBFB (0.62) | METAP1METAP2NPC1RAB9APKM | |
| SCHEMBL23704308 | 0.83 | METAP2 (0.61) | METAP1METAP2NPC1RAB9APKM | |
| SCHEMBL17525961 | 0.82 | METAP2 (0.60) | METAP1METAP2NPC1RAB9APKM | |
| SCHEMBL19970738 | 0.81 | CBFB (0.58) | METAP1METAP2NPC1RAB9APKM | |
| SCHEMBL6616899 | 0.80 | CBFB (0.60) | METAP1METAP2NPC1RAB9APKM | |
| SCHEMBL124197 | 0.78 | CBFB (0.78) | METAP1METAP2NPC1RAB9APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3670509-B1 | INHIBITORS OF INV(16) LEUKEMIA | UNIV VIRGINIA PATENT FOUNDATION (US) | 2023-04-19 | — | — | EP | disclosed |
| EP-3670509-A1 | INHIBITORS OF INV(16) LEUKEMIA | The University of Virginia Patent Foundation (US) | 2020-06-24 | — | — | EP | disclosed |
| US-9926290-B2 | Inhibitors of INV(16) leukemia | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2018-03-27 | — | — | US | disclosed |