Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 5/20 | 0.52 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | PIR | O00625 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.49 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.49 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.49 |
| ▸ | STK16 | O75716 | 1/20 | 0.49 |
| ▸ | OXSR1 | O95747 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | FES | P07332 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | YES1 | P07947 | 1/20 | 0.49 |
| ▸ | LYN | P07948 | 1/20 | 0.49 |
| ▸ | HCK | P08631 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31635978 | 0.88 | PKM (0.49) | BRAFBMPR1BPLK4PIRAURKA | |
| SCHEMBL13888085 | 0.85 | PKM (0.47) | BRAFBMPR1BPLK4PIRAURKA | |
| SCHEMBL17324586 | 0.83 | BRAF (0.49) | BRAFBMPR1BPLK4PIRAURKA | |
| SCHEMBL27795046 | 0.83 | BRAF (0.54) | BRAFBMPR1BPLK4PIRAURKA | |
| SCHEMBL23412702 | 0.83 | F7 (0.56) | BRAFBMPR1BPLK4PIRAURKA | |
| SCHEMBL8478533 | 0.82 | PLK4 (0.44) | BRAFBMPR1BPLK4PIRAURKA | |
| SCHEMBL19997224 | 0.82 | AXL (0.42) | BRAFBMPR1BPLK4PIRAURKA | |
| SCHEMBL9936933 | 0.81 | AXL (0.63) | BRAFBMPR1BPLK4PIRAURKA | |
| SCHEMBL28489988 | 0.80 | JAK2 (0.48) | BRAFBMPR1BPLK4PIRAURKA | |
| SCHEMBL14828891 | 0.80 | BRAF (0.47) | BRAFBMPR1BPLK4PIRAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9926282-B2 | Phthalazinones and isoquinolinones as rock inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-03-27 | — | — | US | disclosed |