Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | ME2 | P23368 | 1/20 | 0.41 |
| ▸ | ME1 | P48163 | 1/20 | 0.41 |
| ▸ | ME3 | Q16798 | 1/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LCAT | P04180 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1733915 | 0.87 | KDM4E (0.61) | HRH3GPR119KDM4EABL1LMNA | |
| SCHEMBL2002031 | 0.86 | HRH3 (0.47) | HRH3GPR119KDM4EABL1LMNA | |
| SCHEMBL11909895 | 0.85 | CHRM4 (0.46) | KDM4EABL1LMNACHRM4PPARG | |
| SCHEMBL1998372 | 0.85 | GPR119 (0.46) | GPR119KDM4EABL1LMNAPPARG | |
| SCHEMBL1844336 | 0.82 | PANK3 (0.49) | GPR119CHRM4 | |
| SCHEMBL1261522 | 0.80 | KDM4E (0.56) | HRH3GPR119KDM4EABL1LMNA | |
| SCHEMBL1998673 | 0.80 | GPR119 (0.54) | HRH3GPR119KDM4EALDH1A1GRM1 | |
| SCHEMBL4882522 | 0.79 | MCHR1 (0.40) | HRH3KDM4EABL1LMNACHRM4 | |
| SCHEMBL3939344 | 0.79 | NPY5R (0.34) | HRH3GPR119KDM4EABL1LMNA | |
| SCHEMBL16924877 | 0.78 | USP30 (0.42) | HRH3KDM4EABL1LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960380-B2 | Non-anilinic derivatives of isothiazol-3(2H)-one 1,1-dioxides as liver X receptor modulators | ASTRAZENECA AB (SE) | 2011-06-14 | — | — | US | disclosed |