Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1951591 | 0.93 | GPR119 (0.49) | GPR119KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL2002526 | 0.87 | GRM1 (0.46) | GPR119KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL2002031 | 0.81 | HRH3 (0.47) | GPR119KDM4EALDH1A1SMN1; SMN2HRH3 | |
| SCHEMBL2006488 | 0.81 | FFAR4 (0.53) | KDM4EALDH1A1OPRD1HRH3 | |
| SCHEMBL1998372 | 0.80 | GPR119 (0.46) | GPR119KDM4E | |
| SCHEMBL2000005 | 0.80 | HRH3 (0.48) | GPR119KDM4EALDH1A1HRH3GRM1 | |
| SCHEMBL11909895 | 0.80 | CHRM4 (0.46) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1026722 | 0.79 | TRPV1 (0.45) | GPR119OPRD1HRH3 | |
| SCHEMBL1733915 | 0.79 | KDM4E (0.61) | GPR119KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6282474 | 0.78 | GPR119 (0.47) | GPR119KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960380-B2 | Non-anilinic derivatives of isothiazol-3(2H)-one 1,1-dioxides as liver X receptor modulators | ASTRAZENECA AB (SE) | 2011-06-14 | — | — | US | disclosed |