Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 5/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.47 |
| ▸ | ACACB | O00763 | 4/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3092882 | 0.87 | CHRNB2 (0.57) | CHRNB2CHRNA4ACACBGPR119CHRNB4 | |
| SCHEMBL11956896 | 0.83 | GPR119 (0.44) | CHRNB2CHRNA4ACACBGPR119CHRNB4 | |
| SCHEMBL11956879 | 0.80 | GPR119 (0.57) | ACACBGPR119 | |
| SCHEMBL11956894 | 0.78 | GPR119 (0.43) | ACACBGPR119 | |
| SCHEMBL11956900 | 0.78 | GPR119 (0.54) | ACACBGPR119CNR2 | |
| SCHEMBL16481200 | 0.77 | KCNH2 (0.53) | — | |
| SCHEMBL3098995 | 0.76 | GPR119 (0.63) | ACACBGPR119MAPT | |
| SCHEMBL15918785 | 0.76 | CHRNB2 (0.51) | CHRNB2CHRNA4ACACBMAPTCHRNB4 | |
| SCHEMBL20000628 | 0.75 | ACACB (0.47) | CHRNB2CHRNA4ACACBMAPTCHRNB4 | |
| SCHEMBL25416857 | 0.75 | CHRNB2 (0.50) | CHRNB2CHRNA4LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997024-B1 | PYRROLIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | BOEHRINGER INGELHEIM INT (DE) | 2018-03-28 | — | — | EP | disclosed |