SCHEMBL2000058

SCHEMBL2000058

O=C(O)c1ccc(Nc2ccccc2)cc1O

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.63
PKM P14618 1/20 0.63
XDH P47989 4/20 0.60
SLC22A12 Q96S37 4/20 0.60
HNF4A P41235 1/20 0.55
ACMSD Q8TDX5 1/20 0.55
ALDH1A1 P00352 3/20 0.52
KDM4E B2RXH2 2/20 0.52
MEN1 O00255 1/20 0.52
POLB P06746 1/20 0.52
GAA P10253 1/20 0.52
HSD17B10 Q99714 1/20 0.52
TDP1 Q9NUW8 1/20 0.52
CA12 O43570 2/20 0.52
CA1 P00915 2/20 0.52
CA2 P00918 2/20 0.52
TSHR P16473 2/20 0.52
CA7 P43166 2/20 0.52
CA9 Q16790 2/20 0.52
CA14 Q9ULX7 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9629955 0.89 ALDH1A1 (0.54) KMT2APKMXDHSLC22A12HNF4A
SCHEMBL2586289 0.85 ALDH1A1 (0.58) KMT2AHNF4AACMSDALDH1A1KDM4E
SCHEMBL8618268 0.85 CASP3 (0.53) KMT2AXDHSLC22A12ALDH1A1MEN1
SCHEMBL27555322 0.84 MAPK13 (0.62) KMT2APKMXDHSLC22A12ALDH1A1
SCHEMBL1129597 0.82 KMT2A (0.69) KMT2APKMMEN1POLBTSHR
SCHEMBL290411 0.82 CA1 (0.54) KMT2APKMALDH1A1KDM4EMEN1
SCHEMBL28472949 0.81 AKR1C3 (0.64) ALDH1A1KDM4EGAAHSD17B10MAPT
SCHEMBL28556076 0.80 AKR1C3 (0.56) KMT2APKMALDH1A1MEN1TDP1
SCHEMBL7094909 0.80 ALDH1A1 (0.56) KMT2APKMXDHSLC22A12ALDH1A1
SCHEMBL11736669 0.80 NR4A1 (0.53) KMT2APKMXDHSLC22A12ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230003721-A1 MITOTHERAPEUTICS FOR THE TREATMENT OF BRAIN DISORDERS THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. 2023-01-05 US disclosed
WO-2021113127-A2 MITOTHERAPEUTICS FOR THE TREATMENT OF BRAIN DISORDERS THE SCRIPPS RESEARCH INSTITUTE (US) 2021-06-10 WO disclosed
EP-2366004-B1 LUBRICATING COMPOSITION CONTAINING A POLYMER FUNCTIONALISED WITH A CARBOXYLIC ACID AND AN AROMATIC POLYAMINE LUBRIZOL CORP (US) 2019-08-07 EP disclosed
CN-105764883-B Thermoplastic polymer composition 美利肯公司 2019-06-04 CN disclosed
CN-105764971-B Thermoplastic polymer composition 美利肯公司 2018-04-06 CN disclosed
CN-105745264-B Thermoplastic polymer composition 美利肯公司 2018-03-13 CN disclosed
EP-1778822-B1 DISPERSANT VISCOSITY MODIFIERS CONTAINING AROMATIC AMINES LUBRIZOL CORP (US) 2018-01-10 EP disclosed
CN-105745189-B Thermoplastic polymer composition 美利肯公司 2017-11-21 CN disclosed
EP-2576741-B1 LUBRICATION METHOD LUBRIZOL CORP (US) 2017-08-23 EP disclosed
CN-105764883-A Thermoplastic polymer composition 美利肯公司 2016-07-13 CN disclosed
EP-2222825-A2 LUBRICATING COMPOSITION CONTAINING A POLYMER The Lubrizol Corporation (US) 2010-09-01 EP disclosed
WO-2010062842-A1 LUBRICATING COMPOSITION CONTAINING A POLYMER FUNCTIONALISED WITH A CARBOXYLIC ACID AND AN AROMATIC POLYAMINE THE LUBRIZOL CORPORATION (US) 2010-06-03 WO disclosed
WO-2009064685-A2 LUBRICATING COMPOSITION CONTAINING A POLYMER THE LUBRIZOL CORPORATION (US) 2009-05-22 WO disclosed
US-20080051520-A1 ALKYL ACRYLATE COPOLYMER VI MODIFIERS AND USES THEREOF AFTON CHEMICAL CORPORATION (US) 2008-02-28 US disclosed
US-20080033114-A1 Alkyl acrylate copolymer VI modifiers and uses thereof AFTON CHEMICAL CORPORATION 2008-02-07 US disclosed
US-20080026964-A1 ALKYL ACRYLATE COPOLYMER VI MODIFIERS AND USES THEREOF AFTON CHEMICAL CORPORATION (US) 2008-01-31 US disclosed
EP-1778822-A1 DISPERSANT VISCOSITY MODIFIERS CONTAINING AROMATIC AMINES The Lubrizol Corporation (US) 2007-05-02 EP disclosed
WO-2006015130-A1 DISPERSANT VISCOSITY MODIFIERS CONTAINING AROMATIC AMINES THE LUBRIZOL CORPORATION (US) 2006-02-09 WO disclosed
US-20060025316-A1 Dispersant viscosity modifiers containing aromatic amines THE LUBRIZOL CORPORATION (US) 2006-02-02 US disclosed
WO-2002084288-A2 INDIVIDUALIZATION OF THERAPY WITH ANTIARRHYTHMICS MCGILL UNIVERSITY (CA) 2002-10-24 WO disclosed