Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20000835 | 0.90 | ALDH1A1 (0.36) | NPC1RAB9AALDH1A1L3MBTL1CACNA1B | |
| SCHEMBL4476857 | 0.90 | NPC1 (0.40) | NPC1RAB9AALDH1A1L3MBTL1CACNA1B | |
| SCHEMBL6231541 | 0.85 | PIN1 (0.41) | NPC1RAB9AALDH1A1L3MBTL1MEN1 | |
| SCHEMBL13708577 | 0.84 | NPC1 (0.37) | NPC1RAB9AALDH1A1L3MBTL1CACNA1B | |
| SCHEMBL20000833 | 0.84 | MCL1 (0.36) | NPC1RAB9AALDH1A1L3MBTL1CA12 | |
| SCHEMBL20000836 | 0.83 | POLB (0.34) | NPC1RAB9AALDH1A1L3MBTL1MEN1 | |
| SCHEMBL20000838 | 0.83 | KCNA5 (0.42) | ALDH1A1KMT2ALMNAFFAR1KCNA5 | |
| SCHEMBL4473008 | 0.82 | ALDH1A1 (0.36) | NPC1RAB9AALDH1A1L3MBTL1MEN1 | |
| SCHEMBL4459334 | 0.80 | NPC1 (0.39) | NPC1RAB9AALDH1A1L3MBTL1CACNA1B | |
| SCHEMBL4468907 | 0.80 | NPC1 (0.38) | NPC1RAB9AALDH1A1L3MBTL1CACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018058109-A1 | COMPOSITIONS AND METHODS FOR TREATING METABOLIC DISORDERS | NUSIRT SCIENCES, INC. (US) | 2018-03-29 | — | — | WO | disclosed |