Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9202983 | 0.86 | KMT2A (0.54) | KMT2AMEN1HSD17B10SMN1; SMN2LMNA | |
| SCHEMBL1401256 | 0.86 | FKBP1A (0.58) | KMT2AMEN1HSD17B10SMN1; SMN2LMNA | |
| SCHEMBL8223617 | 0.86 | FKBP1A (0.58) | KMT2AMEN1HSD17B10SMN1; SMN2LMNA | |
| SCHEMBL440340 | 0.86 | FKBP1A (0.58) | KMT2AMEN1HSD17B10SMN1; SMN2LMNA | |
| SCHEMBL28915732 | 0.84 | KMT2A (0.55) | KMT2AMEN1HSD17B10SMN1; SMN2LMNA | |
| SCHEMBL28916508 | 0.84 | KMT2A (0.55) | KMT2AMEN1HSD17B10SMN1; SMN2LMNA | |
| SCHEMBL28581241 | 0.84 | KMT2A (0.55) | KMT2AMEN1HSD17B10SMN1; SMN2LMNA | |
| SCHEMBL21452369 | 0.83 | KMT2A (0.60) | KMT2AMEN1HSD17B10SMN1; SMN2LMNA | |
| SCHEMBL28486352 | 0.83 | KMT2A (0.60) | KMT2AMEN1HSD17B10SMN1; SMN2LMNA | |
| SCHEMBL24358344 | 0.82 | FKBP1A (0.64) | KMT2AMEN1HSD17B10SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019112457-A1 | DOPAMINE-Β-HYDROXYLASE INHIBITORS | BIAL - PORTELA & Cª, S.A. (PT) | 2019-06-13 | — | — | WO | disclosed |
| WO-2018056854-A1 | BLOOD-BRAIN BARRIER-PENETRANT DOPAMINE-B-HYDROXYLASE INHIBITORS | BIAL - PORTELA & Cª, S.A. (PT) | 2018-03-29 | — | — | WO | disclosed |
| WO-2018056855-A1 | DOPAMINE-B-HYDROXYLASE INHIBITORS | BIAL - PORTELA & Cª, S.A. (PT) | 2018-03-29 | — | — | WO | disclosed |