Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 18/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19388050 | 0.77 | RORC (0.53) | RORCNR1I2 | |
| SCHEMBL1104966 | 0.77 | MAOA (0.59) | MAOAMAOB | |
| SCHEMBL16875313 | 0.75 | RORC (0.62) | RORCNR1I2 | |
| SCHEMBL776308 | 0.73 | MAOB (0.59) | MAOAMAOB | |
| SCHEMBL16799942 | 0.73 | RORC (0.51) | RORCNR1I2MAOAMAOB | |
| SCHEMBL3889144 | 0.72 | MAPT (0.54) | MAOAMAOB | |
| SCHEMBL20002914 | 0.71 | RORC (0.41) | RORCNR1I2 | |
| SCHEMBL31073289 | 0.70 | TSHR (0.60) | MAOAMAOB | |
| SCHEMBL28343856 | 0.70 | RORC (0.48) | RORCNR1I2 | |
| SCHEMBL18275103 | 0.70 | NR4A2 (0.51) | RORCNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |