Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 2/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 7/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 7/20 | 0.44 |
| ▸ | PGR | P06401 | 6/20 | 0.44 |
| ▸ | AR | P10275 | 3/20 | 0.40 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.38 |
| ▸ | CETP | P11597 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | CFB | P00751 | 1/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19387995 | 0.85 | AR (0.43) | RORCNR3C1NR3C2PGRAR | |
| SCHEMBL20002764 | 0.83 | NR3C1 (0.46) | RORCNR3C1NR3C2PGRCETP | |
| SCHEMBL16892231 | 0.79 | AR (0.47) | RORCNR3C1NR3C2PGRAR | |
| SCHEMBL1715169 | 0.76 | IDO1 (0.51) | RORCARPTGES2SLC6A4 | |
| Hydrochloric Acid SCHEMBL1715038 | 0.75 | IDO1 (0.53) | RORCARPTGES2SLC6A4 | |
| SCHEMBL1855982 | 0.74 | AR (0.49) | ARPTGES2SLC6A4TRPV4 | |
| SCHEMBL7667004 | 0.72 | AR (0.47) | NR3C1NR3C2PGRARPTGES2 | |
| SCHEMBL3288455 | 0.72 | AR (0.47) | ARPTGES2SLC6A4 | |
| SCHEMBL22481567 | 0.72 | AR (0.47) | NR3C1NR3C2PGRARPTGES2 | |
| SCHEMBL3571001 | 0.72 | AR (0.47) | PGRARCFBTRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |