Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 2/20 | 0.46 |
| ▸ | PGR | P06401 | 2/20 | 0.46 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.46 |
| ▸ | RORC | P51449 | 4/20 | 0.44 |
| ▸ | CETP | P11597 | 2/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19387997 | 0.86 | NR3C1 (0.43) | NR3C1PGRNR3C2RORCFFAR1 | |
| SCHEMBL20002979 | 0.83 | RORC (0.47) | NR3C1PGRNR3C2RORCCETP | |
| SCHEMBL20002813 | 0.80 | IDO1 (0.53) | NR3C1PGRNR3C2RORCIDO1 | |
| SCHEMBL3641589 | 0.78 | NR3C1 (0.43) | NR3C1PGRNR3C2RORCFFAR1 | |
| SCHEMBL29506809 | 0.78 | NR3C1 (0.43) | NR3C1PGRNR3C2RORCFFAR1 | |
| SCHEMBL23286946 | 0.75 | FFAR1 (0.41) | NR3C1PGRNR3C2RORCFFAR1 | |
| SCHEMBL1715728 | 0.74 | IDO1 (0.59) | NR3C1PGRNR3C2RORCFFAR1 | |
| SCHEMBL13315163 | 0.74 | NR3C1 (0.48) | NR3C1PGRNR3C2KIF11FFAR1 | |
| SCHEMBL21086643 | 0.74 | FFAR1 (0.39) | NR3C1PGRNR3C2RORCFFAR1 | |
| SCHEMBL16841663 | 0.74 | FFAR1 (0.40) | NR3C1PGRNR3C2RORCCETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |