Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 18/20 | 0.60 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | RBP1 | P09455 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20003518 | 1.00 | TRPV4 (0.60) | TRPV4TRPM8KCNH2RBP1 | |
| SCHEMBL23613871 | 1.00 | TRPV4 (0.60) | TRPV4TRPM8KCNH2RBP1 | |
| SCHEMBL20003572 | 0.88 | TRPV4 (0.50) | TRPV4TRPM8RBP1 | |
| SCHEMBL23613838 | 0.88 | TRPV4 (0.50) | TRPV4TRPM8RBP1 | |
| SCHEMBL20003562 | 0.88 | TRPV4 (0.51) | TRPV4TRPM8KCNH2RBP1 | |
| SCHEMBL20003557 | 0.84 | TRPV4 (0.59) | TRPV4TRPM8KCNH2 | |
| SCHEMBL23176162 | 0.84 | PKM (0.54) | TRPV4TRPM8RBP1 | |
| SCHEMBL20007988 | 0.84 | TRPV4 (0.58) | TRPV4 | |
| SCHEMBL20003550 | 0.84 | TRPV4 (0.58) | TRPV4 | |
| SCHEMBL20003513 | 0.84 | TRPV4 (0.61) | TRPV4TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018055526-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |