Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 8/20 | 0.47 |
| ▸ | MET | P08581 | 11/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | AXL | P30530 | 2/20 | 0.43 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18256931 | 0.85 | MET (0.63) | METKDRRETKITPDGFRA | |
| SCHEMBL20003601 | 0.84 | MET (0.60) | BRAFMETKDRRETKIT | |
| SCHEMBL30462276 | 0.79 | BRAF (0.51) | BRAFMETFLT3 | |
| SCHEMBL9909781 | 0.79 | BRAF (0.51) | BRAFMETFLT3 | |
| SCHEMBL15015146 | 0.75 | MET (0.62) | METKDRRETKITPDGFRA | |
| SCHEMBL2931112 | 0.74 | BRAF (0.79) | BRAFKDR | |
| SCHEMBL2931848 | 0.74 | BRAF (0.46) | BRAF | |
| SCHEMBL23070949 | 0.73 | BRAF (0.53) | BRAF | |
| SCHEMBL20003970 | 0.72 | MET (0.49) | BRAFMETKDRRETKIT | |
| SCHEMBL18256933 | 0.72 | MET (0.62) | METKDRRETKITPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299369-A1 | PYRIDO-AZAHETERECYDIC COMPOUND AND PREPARATION METHOD AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2018-03-28 | — | — | EP | disclosed |