Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 18/20 | 0.49 |
| ▸ | KDR | P35968 | 7/20 | 0.49 |
| ▸ | AXL | P30530 | 6/20 | 0.49 |
| ▸ | MERTK | Q12866 | 2/20 | 0.47 |
| ▸ | KIT | P10721 | 4/20 | 0.45 |
| ▸ | FLT3 | P36888 | 4/20 | 0.45 |
| ▸ | RET | P07949 | 3/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | STK25 | O00506 | 1/20 | 0.45 |
| ▸ | CIT | O14578 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | CHUK | O15111 | 1/20 | 0.45 |
| ▸ | MUSK | O15146 | 1/20 | 0.45 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20003727 | 0.87 | MET (0.60) | METKDRAXLMERTKKIT | |
| SCHEMBL18256865 | 0.81 | MET (0.65) | METKDRAXLMERTKKIT | |
| SCHEMBL20003724 | 0.80 | MET (0.60) | METKDRAXLMERTKKIT | |
| SCHEMBL18256925 | 0.77 | MET (0.59) | METKDRAXLMERTKKIT | |
| SCHEMBL18256959 | 0.76 | MET (0.67) | METKDRAXLMERTKKIT | |
| SCHEMBL22521160 | 0.74 | MET (0.65) | METKDRAXLMERTKKIT | |
| SCHEMBL22521169 | 0.74 | MET (0.64) | METKDRAXLMERTKKIT | |
| SCHEMBL20003650 | 0.72 | BRAF (0.47) | METKDRAXLMERTKKIT | |
| SCHEMBL24240709 | 0.72 | MET (0.62) | METKDRAXLMERTKKIT | |
| SCHEMBL22521243 | 0.72 | HDAC2 (0.65) | METKDRAXLMERTKKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299369-A1 | PYRIDO-AZAHETERECYDIC COMPOUND AND PREPARATION METHOD AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2018-03-28 | — | — | EP | disclosed |