Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.41 |
| ▸ | TEK | Q02763 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30074470 | 0.87 | POLB (0.58) | POLBKMT2AMEN1NPSR1GAA | |
| SCHEMBL18256911 | 0.86 | KDR (0.52) | METRAB9ANPC1KDREPHB4 | |
| SCHEMBL13368505 | 0.85 | NPC1 (0.51) | POLBKMT2AMEN1NPSR1MET | |
| SCHEMBL29693549 | 0.85 | MET (0.54) | METKDREPHB4TEKAURKB | |
| SCHEMBL4401200 | 0.85 | MET (0.54) | METKDREPHB4TEKAURKB | |
| SCHEMBL23136503 | 0.81 | MET (0.53) | KMT2AMETRAB9ANPC1KDR | |
| SCHEMBL18256946 | 0.81 | MET (0.54) | METKDRTEKFLT1AURKB | |
| SCHEMBL13926132 | 0.80 | NPC1 (0.54) | POLBKMT2AMEN1NPSR1MET | |
| SCHEMBL28511547 | 0.79 | POLB (0.51) | POLBKMT2AMEN1NPSR1GAA | |
| SCHEMBL30555191 | 0.79 | POLB (0.51) | POLBKMT2AMEN1NPSR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299369-A1 | PYRIDO-AZAHETERECYDIC COMPOUND AND PREPARATION METHOD AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2018-03-28 | — | — | EP | disclosed |